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Parameters used to characterise the antitumour efficacy:

The following read-out parameters are used for the evaluation of antitumour efficacy of a therapeutic intervention:

Survival time:
Mice are euthanised at moribund stage; mean and median survival times are calculated (mainly used for syngeneic models)

Tumour growth inhibition:
Tumour diameters are measured with an electronic calliper at defined days throughout the experimental period. Individual tumour volumes are calculated according to (length x width2) x 0.5. Relative tumour volumes (RTV) are calculated in relation of each measurement to the first measurement at initiation of treatment.

Tumour growth delay:
Days needed to reach a defined tumour size are determined both in control and drug-treated groups, T (treated) / C (control) values are calculated.

Tumour doubling time:
The median time to reach two tumour volume doublings is determined.

Tumour weight:
The tumour wet weight is determined at the end of experiment.

Take rate/Latency period:
Number or percentage of mice with progressive tumour growth is determined as take rate.
The time until tumour growth commences is defined as latency period.

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