Side effects

EPO-GmbH has experience with the determination of following side effects exerted in rodents after treatment with potential cytotoxic compounds:

Clinicopathological observations in mice (detailed description)

Body weight (gastrointestinal, liver toxicity)

Blood parameter (bone marrow toxicity, determined with Coulter counter):

Abbreviation Description Unit

WBC

Total White Blood Cells

x 10⁶/ml

RBC

Red Blood Cells

x 10⁶/µl

HGB

Haemoglobin

g/dl

HCT

Haematocrit

%

MCV

Mean Corpuscular Volume

fl

MCH

Mean Corpuscular Haemoglobin

pg

MCHC

Mean Corpuscular Haemoglobin Concentration

g/dl

PLT

Platelets

x 10⁶/ml

Blood and bone marrow differentiation.

Colony forming capacity of bone marrow (bone marrow toxicity)

Blood chemistry (e.g. glucose, ALAT, ASAT, BUN, creatinine)

Autopsy/Necropsy (detailed description of gross observations)

Pathology/histology of paraffin-embedded tissues

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Abbreviation	Description	Unit
WBC	Total White Blood Cells	x 10⁶/ml
RBC	Red Blood Cells	x 10⁶/µl
HGB	Haemoglobin	g/dl
HCT	Haematocrit	%
MCV	Mean Corpuscular Volume	fl
MCH	Mean Corpuscular Haemoglobin	pg
MCHC	Mean Corpuscular Haemoglobin Concentration	g/dl
PLT	Platelets	x 10⁶/ml