Xenografts


Nude mice with human colon cancer xenografts	NOD/SCID mice xenotransplanted with a human leukaemia

More than 100 human tumour models of different localisations and types are available including:

Bladder, breast, colon, endometrium, fibrosarcoma, glioma, head&neck (tongue), leukaemia (ALL, AML), liver, lung, melanoma, mesothelioma, neuroblastoma, ovarian, prostate, rhabdomyosarcoma, renal, sarcoma, stomach and vulva.

The xenografts are characterised for growth, chemo-responsiveness and, partially, for expression of tumour markers.

Most xenografts are derived from cell lines.

Additionally, EPO-GmbH has established a variety of unique patient-derived xenografts. For that purpose, fresh surgical specimens were transplanted directly to immunodeficient mice. For therapeutic experiments only early-passaged tumours are used which resemble closely the original malignomas.

EPO-GmbH offers further the establishment of xenografts from customer-submitted cell lines or tumour material.

Available human tumours as xenografts in immunodeficient mice:

Type	Code	Mouse strain	Inoculation	Metastasis
Bladder	RT4 T24 UM-UC3	nude nude nude	s.c. s.c. s.c.
Breast	MCF-7 MDA-MB 435 MDA-MB 231 T47D ZR-75-1 10 patient-derived models	nude nude nude nude nude nude	s.c., orthotopic s.c. s.c., orthotopic s.c. s.c. s.c.	X X
Colon	LoVo Ls174T HT29 HCT116 HCT-8 HCT-15 SW480 20 patient-derived models	nude nude nude nude nude nude NOD/SCID nude	s.c., orthotopic s.c., orthotopic s.c., i.v., i.splen. s.c. s.c. s.c. s.c., i.splen. s.c.	(X) X X X
Endometrium	HEC 1B	nude	s.c.
Fibrosarcoma	HT1080	nude	s.c.
Glioma	U87 U373 U343 T23/96	nude nude nude nude	s.c., orthotopic s.c., orthotopic s.c. s.c.
Head&neck (tongue)	CRL-1624	nude	s.c.
Leukaemia (ALL)	REH SUP-B15 SU-DHL-4 Raji Burkitt lymphoma NALM-6 KARPAS 299 IM-9 myeloma 12 patient-derived models	NOD/SCID NOD/SCID NOD/SCID NOD/SCID NOD/SCID NOD/SCID NOD/SCID NOD/SCID	i.v. i.v. i.v. i.v. i.v., s.c. s.c. s.c. i.v., s.c.	X X X X
Leukaemia (AML)	EOL-1 HL-60 5 patient-derived models	NOD/SCID NOD/SCID NOD/SCID	i.v., s.c. i.v. i.v., s.c.	X X X
Liver	HEK 239	nude	s.c.
Lung	A549 HCT-19 HCT-8 NCI-H69 NCI-H460 NCI-H209 NCI-H1975 23 patient-derived models	nude nude nude nude nude nude nude nude	s.c. s.c. s.c. s.c. s.c. s.c. s.c. s.c., orthotopic ,i.cer.
Melanoma	A 375 MV-3 M 13 MeWo WM98-1 1956 2092 4988	nude nude nude nude nude nude nude nude	s.c., i.v. s.c., i.v. s.c. s.c. s.c. s.c. s.c. s.c.	X
Mesothelioma	1503 7212 7648	nude nude nude	s.c. s.c. s.c.
Neuroblastoma	IMR5-75 Kelly	nude nude	s.c. s.c.
Ovarian	A2780 OVCAR-3 HOC-22 2922 6 patient-derived models	nude nude nude nude NOD/SCID	i.p., s.c. i.p., s.c. i.p., s.c. i.p., s.c. s.c.
Pancreas	PANC-1 BxPC-3 AsPC-1 PaTU PSN-1	nude nude nude nude nude	s.c., orthotopic s.c. s.c. s.c. s.c.	X
Prostate	DU 145 PC-3 LnCAP CWR22	nude nude nude NOD/SCID	s.c., orthotopic s.c., orthotopic s.c., orthotopic s.c., orthotopic	X
Rhabdomyosarcoma	A673	nude	s.c.
Renal	Caki-1	nude	s.c.
Sarcoma	10 patient-derived models	nude	s.c.
Stomach	Kato III 7268	NOD/SCID nude	s.c. s.c.
Vulva	A431	nude	s.c.

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