Xenografts

More than 200 human tumour models of different localisations and types are available including:

Bladder, breast, colon, endometrium, fibrosarcoma, glioma, head&neck (tongue), leukaemia (ALL, AML), liver, lung, melanoma, mesothelioma, neuroblastoma, ovarian, prostate, rhabdomyosarcoma, renal, sarcoma, stomach and vulva.

The xenografts are characterised for growth, chemo-responsiveness and, partially, for expression of tumour markers.

Most xenografts are derived from cell lines.

Additionally, EPO-GmbH has established a variety of unique patient-derived xenografts. For that purpose, fresh surgical specimens were transplanted directly to immunodeficient mice. For therapeutic experiments only early-passaged tumours are used which resemble closely the original malignomas.

EPO-GmbH offers further the establishment of xenografts from customer-submitted cell lines or tumour material.

Available human tumours as xenografts in immunodeficient mice:

Type	Code	Mouse strain	Inoculation	Metastasis
Bladder	RT4	nude	s.c.
	T24	nude	s.c.
	UM-UC3	nude	s.c.
Breast	MCF-7	nude	s.c., orthotopic
	MDA-MB 435	nude	s.c.	X
	MDA-MB 231	nude	s.c., orthotopic
	T47D	nude	s.c.
	ZR-75-1	nude	s.c.	X
	MT-3	nude	s.c.,i.v.	X
	KPL-4	nude	s.c.,orthotopic
	BT-474	nude	s.c.,orthotopic
	10 patient-derived models	nude	s.c.
Colon	LoVo	nude	s.c., orthotopic	(X)
	Ls174T	nude	s.c., orthotopic	X
	HT29	nude	s.c., i.v., i.splen.	X
	HCT116	nude	s.c.
	HCT-8	nude	s.c.
	HCT-15	nude	s.c.
	SW480	NOD/SCID	s.c., i.splen.	X
	SW620	nude	s.c.
	26 patient-derived models	nude	s.c.
Endometrium	HEC 1B	nude	s.c.
Fibrosarcoma	HT1080	nude	s.c.
Gastric	N87	nude	s.c.
	MKN-28	nude	s.c.
	MKN-45	nude	s.c.
	7268 (patient-der.)	nude	s.c.
	1478 (patient-der.)	nude	s.c.
Glioma	U87	nude	s.c., orthotopic
	U373	nude	s.c., orthotopic
	U343	nude	s.c.
	T23/96	nude	s.c.
Head&neck (tongue)	CRL-1624	nude	s.c.
Leukaemia (ALL)	REH	NOD/SCID	i.v.
	SUP-B15	NOD/SCID	i.v.
	SU-DHL-4	NOD/SCID	i.v.	X
	NALM-6	NOD/SCID	i.v., s.c.	X
	KARPAS 299	NOD/SCID	s.c.
	IM-9 myeloma	NOD/SCID	s.c.
	12 patient-derived models	NOD/SCID	i.v., s.c.	X
Leukaemia (AML)	EOL-1	NOD/SCID	i.v., s.c.	X
	HL-60	NOD/SCID	i.v.	X
	5 patient-derived models	NOD/SCID	i.v., s.c.	X
Leukemia (CML)	K562	NOD/SCID	i.v., s.c.	X
Lymphoma (B-cell)	Jeko-1	NOD/SCID	s.c.
	DOHH-2	NOD/SCID	s.c.
	Daudi	NOD/SCID	s.c.
	Raji Burkitt	NOD/SCID	i.v.	X
Liver	HEK 239	nude	s.c.
Lung (NSCLC)	A549	nude	s.c.
	NCI-H69	nude	s.c.
	NCI-H460	nude	s.c.
	NCI-H209	nude	s.c.
	NCI-H1975	nude	s.c.
	24 patient-derived models	nude	s.c., orthotopic, i.cer.
Lung (SCLC)	NCI-H69	nude	s.c.
	NCI-H209	nude	s.c.
	DMS53	nude	s.c.
Melanoma	A 375	nude	s.c., i.v.
	MV-3	nude	s.c., i.v.	X
	M 13	nude	s.c.
	MeWo	nude	s.c.
	WM98-1	nude	s.c.
	1956	nude	s.c.
	2092	nude	s.c.
	4988	nude	s.c.
Mesothelioma	1503	nude	s.c.
	7212	nude	s.c.
	7648	nude	s.c.
Neuroblastoma	IMR5-75	nude	s.c.
	SK-N-SH	nude	s.c.
	Kelly	nude	s.c.
Ovarian	A2780	nude	i.p., s.c.
	OVCAR-3	nude	i.p., s.c.
	HOC-22	nude	i.p., s.c.
	2922	nude	i.p., s.c.
	OVCAR-8	nude	i.p., s.c.
	6 patient-derived models	NOD/SCID	s.c.
Pancreas	PANC-1	nude	s.c., orthotopic	X
	BxPC-3	nude	s.c.
	AsPC-1	nude	s.c.
	Patu 8902	nude	s.c.
	PSN-1	nude	s.c.
Prostate	DU 145	nude	s.c., orthotopic
	PC-3	nude	s.c., orthotopic	X
	LnCAP	nude	s.c., orthotopic
	CWR22	NOD/SCID	s.c., orthotopic
Rhabdomyosarcoma	A673	nude	s.c.
Renal	Caki-1	nude	s.c.
	786-O	nude	s.c.
Sarcoma	10 patient-derived models	nude	s.c.
Vulva	A431	nude	s.c.

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