Patient- and cell line derived xenografts

  • More than 600 well characterized PDX models of solid and hematological tumors
  • Availability of molecular data, drug response data and clinical data sets
  • CDX models covering all major tumor types

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Immuno-oncology models

  • Broad collection of humanized and syngeneic models
  • In-house humanization with various immune cell populations
  • Supporting in vitro cell assays with the Incucyte® Live-Cell Analysis System

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Orthotopic models

  • Monitoring of tumor progression by bioluminescence imaging (BLI), ultra sound and flow cytometry
  • Orthotopic models to study metastasis using established protocols

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Radiation Therapy

  • Administration of radiation using the Multirad X-Ray irradiation system to simulate clinically relevant irradiation schedules
  • Permission to conduct in vivo studies with a broad variety of radioisotopes

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Histopathology services

  • Supervision of necropsy procedure by a board-certified pathologist
  • Standard hematoxylin and eosin (H&E) histology including evaluation
  • Immunohistochemistry (IHC) on both frozen and paraffin sections

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Bioinformatics and biostatistics services

  • Gene expression profiling of selected genes or gene signatures
  • HLA matching for immuno-oncology studies 
  • Calculation of optimal sample sizes to achieve sufficient statistical power

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Pharmacokinetic & toxicology studies

  • Broad variety of possible PK study designs for determining a suitable dosing schedule and route of administration
  • Dose escalation studies for Maximum-Tolerated Dose (MTD) determination

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Cell based in vitro assays & molecular analyses

  • In vitro screening in 2D and 3D in a drug concentration and time dependent manner
  • Automated live cell imaging with the IncuCyte® system to evaluate drug action
  • Molecular analyses to identify and to verify target expression on RNA and protein level

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