15th – 17th May 2024

EPO is presenting at the 21st CIMT Annual Meeting in Mainz

Poster #180 : Assessment of therapeutic antibody efficacy without the interference of murine Fc receptors allows for investigation of human antibody-dependent cellular cytotoxicity mediated by NK cells in the FcResolv™ hIL-15 NOG mouse model

In our collaboration project with Taconic Bioscience, we analyzed the antibody efficacy on different tumor models in the new mouse model FcResolvTM hIL-15 NOG that lack the murine Fc receptors and expresses human IL-15. The murine Fc receptors can have positive or negative effects on the treatment efficacies of antibodies. In a following investigation we combined the antibody treatment with NK cell transfer to explore the antibody-dependent cellular cytotoxicity mediated by NK cells. We will present the results on the upcoming CIMT meeting in Mainz in the poster session.

Poster #180 in Poster Session May 16th, 5:00 pm - 7:30 pm.

Presenter: Dr. Simone Rhein