Selected publications

Key publications describing our PDX models

Head and neck squamous cell carcinoma (HNSCC) PDX models

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer.
Klinghammer K, Politz O, Eder T, Otto R, Raguse JD, Albers A, Kaufmann A, Tinhofer I, Hoffmann J, Keller U, Keilholz U.
Oncotarget. 2020 Oct 13;11(41):3688-3697. doi: 10.18632/oncotarget.27763. eCollection 2020 Oct 13.
PMID: 33110476

Basal subtype is predictive for response to cetuximab treatment in patient-derived xenografts of squamous cell head and neck cancer.
Klinghammer K, Otto R, Raguse JD, Albers AE, Tinhofer I, Fichtner I, Leser U, Keilholz U, Hoffmann J.
Int J Cancer. 2017 Sep 15;141(6):1215-1221. doi: 10.1002/ijc.30808. Epub 2017 Jun 21.
PMID: 28560858

A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option.
Klinghammer K, Raguse JD, Plath T, Albers AE, Joehrens K, Zakarneh A, Brzezicha B, Wulf-Goldenberg A, Keilholz U, Hoffmann J, Fichtner I.
Int J Cancer. 2015 Jun 15;136(12):2940-8. doi: 10.1002/ijc.29344. Epub 2014 Nov 26.
PMID: 25404014

Colorectal cancer (CRC) PDX models

Modeling of Personalized Treatments in Colon Cancer Based on Preclinical Genomic and Drug Sensitivity Data.
Keil M, Conrad T, Becker M, Keilholz U, Yaspo ML, Lehrach H, Schütte M, Haybaeck J, Hoffmann J.
Cancers (Basel). 2021 Nov 30;13(23):6018. doi: 10.3390/cancers13236018.
PMID: 34885128

Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Dahlmann M, Gambara G, Brzezicha B, Popp O, Pachmayr E, Wedeken L, Pflaume A, Mokritzkij M, Gül-Klein S, Brandl A, Schweiger-Eisbacher C, Mertins P, Hoffmann J, Keilholz U, Walther W, Regenbrecht C, Rau B, Stein U.
Mol Cancer. 2021 Oct 21;20(1):129. doi: 10.1186/s12943-021-01430-7.
PMID: 34670579

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.
Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.
PMID: 28186126

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.
Rivera M, Fichtner I, Wulf-Goldenberg A, Sers C, Merk J, Patone G, Alp KM, Kanashova T, Mertins P,Hoffmann J, Stein U, Walther W.
Neoplasia. 2021 Jan;23(1):21-35
PMID: 33212364

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle J, Menzel L, Niesler N, Kobelt D, Aumann J, Rivera M, Walther W.
BMC Cancer. 2017 Feb 13;17(1):129. doi: 10.1186/s12885-017-3123-x.
PMID: 28193196

Non-small cell lung cancer (NSCLC) PDX models

Breaking the crosstalk of the Cellular Tumorigenic Network by low-dose combination therapy in lung cancer patient-derived xenografts.
Gürgen D, Conrad T, Becker M, Sebens S, Röcken C, Hoffmann J, Langhammer S.
Commun Biol. 2022 Jan 17;5(1):59. doi: 10.1038/s42003-022-03016-5.
PMID: 35039644

Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.
Fichtner I, Rolff J, Soong R, Hoffmann J, Hammer S, Sommer A, Becker M, Merk J.
Clin Cancer Res. 2008 Oct 15;14(20):6456-68. doi: 10.1158/1078-0432.CCR-08-0138.
PMID: 18927285

Pancreatic ductal adenocarcinoma (PDAC) PDX models

Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE).
Pahle J, Kobelt D, Aumann J, Behrens D, Daberkow O, Mokritzkij M, Piontek J, Stein U, Walther W.
Cancers (Basel). 2021 Aug 31;13(17):4393. doi: 10.3390/cancers13174393.
PMID: 34503203

Pancreatic cancer models for translational research.
Behrens D, Walther W, Fichtner I.
Pharmacol Ther. 2017 May;173:146-158. doi: 10.1016/j.pharmthera.2017.02.013. Epub 2017 Feb 4.
PMID: 28174092

Renal cancer

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier
Nat Commun. 2020; 11: 929. Published online 2020 Feb 17. doi: 10.1038/s41467-020-14700-7
PMID: 33349639

Melanoma

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.
Kobelt D, Aumann J, Schmidt M, Wittig B, Fichtner I, Behrens D, Lemm M, Freundt G, Schlag PM, Walther W.
Mol Oncol. 2014 May;8(3):609-19. doi: 10.1016/j.molonc.2013.12.019. Epub 2014 Jan 18.
PMID: 24503218

Metastasis models

Patient-Derived Xenografts from Solid Tumors (PDX) for Models of Metastasis.
Wulf-Goldenberg A, Hoffmann J, Becker M, Brzezicha B, Walther W.
Methods Mol Biol. 2021;2294:43-58. doi: 10.1007/978-1-0716-1350-4_4.
PMID: 33742393

2022

Mathias Dahlmann, Anne Monks, Erik D. Harris, Dennis Kobelt, Marc Osterland, Fadi Khaireddine, Pia Herrmann, Wolfgang Kemmner, Susen Burock, Wolfgang Walther, Robert H. Shoemaker, Ulrike Stein
Combination of Wnt/beta-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer

(PDF)
(Weblink)

2021

Mathias Dahlmann, Guido Gambara, Bernadette Brzezicha, Oliver Popp, Eva Pachmayr, Lena Wedeken, Alina Pflaume, Margarita Mokritzkij, Safak Gül-Klein, Andreas Brandl, Caroline Schweiger-Eisbacher, Philipp Mertins, Jens Hoffmann, Ulrich Keilholz, Wolfgang Walther, Christian Regenbrecht, Beate Rau, Ulrike Stein
Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models
(PDF)

2020

Jan Budczies, Klaus Kluck, Wolfgang Walther, Ulrike Stein
Decoding and targeting the molecular basis of MACC1-driven metastatic spread: Lessons from big data mining and clinical-experimental approaches
(PDF)

Mathias Dahlmann, Rebecca Werner, Benedikt Kortüm, Dennis Kobelt, Wolfgang Walther and Ulrike Stein
Restoring Treatment Response in Colorectal Cancer Cells by Targeting MACC1-Dependent ABCB1 Expression in Combination Therapy
(PDF)

Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
(PDF)

Moritz Jesinghaus, Katja Steiger, Fabian Stögbauer, Bernhard Haller, Andreas Kolk, Ulrich Straßen, Anja Pickhard, Markus Wirth, Miguel Silva, Jan Budczies, Aaron Becker von Rose, Björn Konukiewitz, Peer Kuhn, Konrad Klinghammer, Hendrik Dapper, Stefan Münch, Stephanie E. Combs, Wilko Weichert, Melanie Boxberg
Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma
(PDF)

Dennis Kobelt, Mathias Dahlmann, Malti Dumbani, Nazli Güllü, Benedikt Kortüm, Miguel E. Alberto Vílchez, Wolfgang Walther, Ulrike Stein
Small Ones to Fight a Big Problem—Intervention of Cancer Metastasis by Small Molecules
(PDF)

Clemens Messerschmidt, Benedikt Obermayer, Konrad Klinghammer, Sebastian Ochsenreither, Denise Treue, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Thomas Kindler, Christian H. Brandts, Klaus Schulze-Osthoff, Wilko Weichert, Ingeborg Tinhofer, Frederick Klauschen, Ulrich Keilholz, Dieter Beule, Damian T. Rieke
Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC
(PDF)

Anna Piontek, Miriam Eichner, Denise Zwanziger, Laura-Sophie Beier, Jonas Protze, Wolfgang Walther, Sarah Theurer, Kurt Werner Schmid, Dagmar Fuhrer-Sakel, Jorg Piontek, Gerd Krause
Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin
(PDF)

Theres Schaub, Dennis Gürgen, Deborah Maus, Claudia Lange, Victor Tarabykin, Duska Dragun & Björn Hegner
Publisher Correction: mTORC1 and mTORC2 Diferentially Regulate Cell Fate Programs to Coordinate Osteoblastic Diferentiation in Mesenchymal Stromal Cells
(PDF)

Iordana A. Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C. Stroe, Zoltán Cseresnyés, Ann-Kathrin Zimmermann, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krüger, Viktòria Szeifert, Sandor Nietzsche, Theresia Conrad, Matthew G. Blango, Olaf Kniemeyer, Marie von Lilienfeld-Toal, Peter F. Zipfel, Erzsébet Ligeti, Marc Thilo Figge, Axel A. Brakhagea
Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus
(PDF)

Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado Garcıa, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Kuenkele, Jana Rolff, Patrick Hundsdorfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen
Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors
(PDF)

Ben Zhao, Laura Dierichs, Jiang-Ning Gu, Marija Trajkovic-Arsic, Ralf Axel Hilger, Konstantinos Savvatakis, Silvia Vega-Rubin-de-Celis, Sven-Thorsten Liffers, Samuel Peña-Llopis, Diana Behrens, Stephan Hahn, Jens T. Siveke, Smiths S. Lueong
TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
(PDF)

2019

Roman Eickhoff, Maria Guschlbauer, Alexandra C. Maul, Christian D. Klink, Ulf P. Neumann, Michael Engel, Martin Hellmich, Anja Sterner-Kock and Christian F. Krieglstein
A new device to prevent fascial retraction in the open abdomen – proof of concept in vivo
(PDF)

Ellen Heitzer, Arwin Groenewoud, Katharina Meditz, Birgit Lohberger, Bernadette Liegl-Atzwanger, Andreas Prokesch, Karl Kashofer, Diana Behrens, Johannes Haybaeck, Dagmar Kolb-Lenz, Harald Koefeler, Sabrina Riedl, Helmut Schaider, Carina Fischer, B. Ewa Snaar-Jagalska, Danielle de’Jong, Karoly Szuhai, Dagmar Zweytick & Beate Rinner
Human melanoma brain metastases cell line MUG-Mel1, isolated clones and their detailed characterization
(PDF)

Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu, Andreas Pohlmann, Jan Hentschel, Karen Arakelyan, Erdmann Seeliger, Bert Flemming, Dennis Gürgen Michael Rothe, Thoralf Niendorf, Vijaya L. Manthati, John R. Falck, Michael Haase, Wolf‐Hagen Schunck, Duska Dragun
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury
(PDF)

Ian C. MacArthur, Yi Bei, Heathcliff Dorado Garcia, Michael V. Ortiz, Joern Toedling, Filippos Klironomos, Jana Rolff, Angelika Eggert, Johannes H. Schulte, Alex Kentsis and Anton G. Henssen
Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma
(PDF)

Harikrishnan Radhakrishnan, Wolfgang Walther, Fabian Zincke, Dennis Kobelt, Francesca Imbastari, Müge Erdem, Benedikt Kortüm, Mathias Dahlmann, Ulrike Stein
MACC1—the first decade of a key metastasis molecule from gene discovery to clinical translation
(PDF)

Shuyun Rao1, Suraj Peri, Jens Hoffmann, Kathy Q. Cai, Bryan Harris, Michele Rhodes, Denise C. Connolly, Joseph R. Testa, David L. Wiest
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance
(PDF)

Theres Schaub, Dennis Gürgen, Deborah Maus, Claudia Lange, VictorTarabykin, Duska Dragun, Björn Hegner
mTORC1 and mTORC2 Diferentially Regulate Cell Fate Programs to Coordinate Osteoblastic Diferentiation in Mesenchymal Stromal Cells
(PDF)

Daniel C. Schroeder, Alexandra C. Maul, Maria Guschlbauer, Simon-Richard Finke, David de la Puente Bethencourt, Tobias Neumann, Stephan A. Padosch, Thorsten Annecke, Bernd W. Boettiger, Anja Sterner-Kock and Holger Herff
Esophageal Heat Exchanger Versus Water-Circulating Cooling Blanket for Targeted Temperature Management
(PDF)

Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Jens Hoffmann, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Melanie Boerries, Reinhold Schaefer, Christian R. A. Regenbrecht
Heterogeneous pathway activation and drug response modelled in colorectal-tumorderived 3D cultures
(PDF)

Daniela Schwarzenbacher, Christiane Klec, Barbara Pasculli, Stefanie Cerk, Beate Rinner, Michael Karbiener, Cristina Ivan, Raffaela Barbano, Hui Ling, Annika Wulf-Goldenberg, Stefanie Stanzer, Gabriel Rinnerthaler, Herbert Stoeger, Thomas Bauernhofer, Johannes Haybaeck, Gerald Hoefler, Stephan Wenzel Jahn, Paola Parrella, George Adrian Calin and Martin Pichler
MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors
(PDF)

Qionghua Zhu, Liang Fang, Julian Heuberger, Andrea Kranz, Joerg Schipper, Kathrin Scheckenbach, Ramon Oliveira Vidal, Daniele Yumi Sunaga-Franze, Marion Muller, Annika Wulf-Goldenberg, Sascha Sauer and Walter Birchmeier
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer
(PDF)

2018

Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunaga-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W.
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer
Cell Rep. 2019 Jan 8;26(2):415-428. doi: 10.1016/j.celrep.2018.12.059 (Weblink)

2017

Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, Pehserl AM, Reicher A, Resel M, Heitzer E, Ivan C, Bullock M, Ling H, Deutsch A, Wulf-Goldenberg A, Adiprasito JB, Stoeger H, Haybaeck J, Svoboda M, Stotz M, Hoefler G, Slaby O, Calin GA, Gerger A, Pichler M
miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.
Clin Cancer Res. 2017 Sep 1;23(17):5255-5266. doi: 10.1158/1078-0432.CCR-17-0023.

Quandt D, Zucht HD, Amann A, Wulf-Goldenberg A, Borrebaeck C, Cannarile M, Lambrechts D, Herbert Oberacher H, Garrett J, Nayak T, Kazinski M, Massie C, Schwarzenbach H, Maio M, Prins R, Wendik B, Hockett R, Enderle D, Noerholm M, Hendriks H, Zwierzina H, Seliger B
Implementing liquid biopsies into clinical decision making for cancer immunotherapy
Oncotarget 2017;8:48507-20 (PDF) (Weblink)

Behrens D., Walther W., Fichtner I. (Published May 2017)
Pancreatic cancer models for translational research.
(PDF) (Weblink)

Moritz Schütte et al.# (Published 10 Feb 2017)
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Nature communications. doi: 10.1038/ncomms14262

Valenti G, Quinn HM, Heynen GJ, Lan L, Holland JD, Vogel R, Wulf-Goldenberg A, Birchmeier W.
Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors.
Cancer Res. 2017 Feb 15. pii: canres.3490.2015. doi: 10.1158/0008-5472.CAN-15-3490. [Epub ahead of print]

2016

Pichler M, Stiegelbauer V, Vychytilova-Faltejskova P, Ivan C, Ling H, Winter E, Zhang X, Goblirsch M, Wulf-Goldenberg A, Ohtsuka M, Haybaeck J, Svoboda M, Okugawa Y, Gerger A, Hoefler G, Goel A, Slaby O, Calin GA.
Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.
Clin Cancer Res. 2016 Sep 6. doi: 10.1158/1078-0432.CCR-16-0497. [Epub ahead of print]

Natalya Beglyarova, Eugenia Banina,Yan Zhou, Ramilia Mukhamadeeva, Grigorii Andrianov, Egor Bobrov, Elena Lysenko1, Natalya Skobeleva, Linara Gabitova, Diana Restifo, Max Pressman, Ilya G. Serebriiskii, John P. Hoffman, Keren Paz, Diana Behrens, Vladimir Khazak, Sandra A. Jablonski, Erica A. Golemis, Louis M. Weiner, and Igor Astsaturov (2016)
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Clim. Cancer Res. 22, 6153

Rolff J, Becker M, Merk J, Hoffmann J, Fichtner I. (2016)
Preclinical Study of a Combination of Erlotinib and Bevacizumab in Early Stages of Unselected Non-Small Cell Lung Cancer Patient-Derived Xenografts
Targ Oncol DOI 10.1007/s11523-015-0415-4

Orthmann A, Peiker L, Fichtner I, Hoffmann A, Hilger RA, Zeisig R. (2016)
Improved treatment of MT-3 breast cancer and brain metastases in a mouse xenograft by LRP-targeted oxaliplatin liposomes
J Biomed Nanotechnol 12, 56-68

Behrens D, Rolff J, Hoffmann J. (2016)
Predictive in vivo models for oncology
Handb Exp Pharmacol. 2015 Oct 22. PMID: 26489829

2015

Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W. (2015)
A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis
Cancer Res. 2015 Dec 8. pii: canres.1519.2015. PMID: 26645562 [Epub ahead of print]

Knöspel F, Freyer N, Stecklum M, Gerlach JC, Zeilinger K. (2015)
Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor
Biotechnol Prog. 2015 Oct 21. doi: 10.1002/btpr.2182. PMID: 26486457 [Epub ahead of print]

Qi J, Yu Y, Akilli Öztürk Ö, Holland JD, Besser D, Fritzmann J, Wulf-Goldenberg A, Eckert K, Fichtner I, Birchmeier W. (2015)
New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals
Gut. 2015 Jul 8. pii: gutjnl-2014-307900. doi: 10.1136/gutjnl-2014-307900. PMID: 26156959 [Epub ahead of print]

Roblek M, Calin M, Schlesinger M, Stan D, Zeisig R, Simionescu M, Bendas G, Borsig L. (2015)
Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis
J Control Release 220, 341-347

Diaz-Miqueli A, Markelova MR, Lemm M, Fichtner I. (2015)
Co-localization of CD133/EGFR and antiangiogenic activity drive the antitumor effect of Nimotuzumab and radiation in human GBM U87MG xenografted in mice
Stem Cells Research, Reviews & Reports 2. ISSN: 2381-9073

Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. (2015)
Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo
Oncogenesis 4(2)e 137

Testen A, Podlipec R, Mravljak J, Orthmann A, Šentjurc M, Zeisig R, Štrancar J, Koklic T. (2015)
How perifosine affects liposome-encapsulated drug delivery across a cell barrier
Therapeutic Delivery 6(4), 423-441

Lan L, Holland JD, Qi J, Grosskopf S, Rademann J, Vogel R, Györffy B, Wulf-Goldenberg A, Birchmeier W. (2015)
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice
The EMBO Journal 34(11), 1493-508

Klinghammer K, Raguse JD, Plath T, Albers AE, Joehrens K, Zakarneh A, Brzezicha B, Wulf-Goldenberg A, Keilholz U, Hoffmann J, Fichtner I. (2015)
A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option
International Journal of Cancer 136(12), 2940-2948

Stecklum M, Wulf-Goldenberg A, Purfürst B, Siegert A, Keil M, Eckert K, Fichtner I. (2015)
Cell differentiation mediated by co-culture of human umbilical cord blood stem cells with murine hepatic cells
In Vitro Cellular & Developmental Biology Animal 51(2), 183-191

Weilemann A, Grau M, Erdmann T, Merkel O, Sobhiafshar U, Anagnostopoulos I, Hummel M, Siegert A, Hayford C, Madle H, Wollert-Wulf B, Fichtner I, Dörken B, Dirnhofer S, Mathas S, Janz M, Emre NC, Rosenwald A, Ott G, Lenz P, Tzankov A, Lenz G. (2015)
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma
Blood 125(1), 124-132