EPO Newsletter

analyses of these models and their response toward drug treatment as well as correlation analyses on drug responsiveness and molecular profiles are presented. This publication demonstrates the value of such PDX models for pre-clinical testing to identify new therapeutic targets, molecular signatures and to evaluate novel therapeutic approaches.

Consulting and published in Communications Biology (Gürgen D et al., Comm Biol 5:59; 2022). Detailed molecular analyses of the NSCLC PDX signaling networks enabled identification of intervention points to more effectively prevent the development of drug resistance of these tumors. Based on this, treatment of EPO’s NSCLC PDXs with a combination of cabozantinib, afatinib, plerixafor and etoricoxib resulted in efficient overcoming of resistance for these tumors and an improved therapeutic outcome. This study is an excellent example that molecular data sets of PDX models can be used effectively for design and testing of novel therapy concepts.

Dear Colleagues,

Unfortunately, the pandemic situation has just once again prevented us from attending the AACR meeting in person and has forced us to cancel our on-site poster presentations.

After a break of more than 3 years due to the pandemic, we were very much looking forward to meeting you again in person at this year's AACR and to share the latest developments on preclinical tumor models at the posters.

If you are attending the AACR, we look forward to a lively online poster discussion with you via the "AACR Annual Meeting 2022: E-Poster" webpage.

For those not attending the meeting, we are sending the link to our posters here:

Poster#1: Humanized mouse models for ...

Poster#2: Breaking the crosstalk of ...

Please contact us with any question: Turn on Javascript!

Best Regards

Jens Hoffmann

CEO