... with clinical partners from Germany and Italy. By this, 45 PC‑PDX models were generated, which in the majority represent ductal adenocarcinomas (PDAC). The mutational profile of the PDXs, the sensitivity of the models toward standard of care (SoC) drugs gemcitabine, 5-fluorouracil, oxaliplatin, and abraxane, and combinations thereof were analyzed and correlated to the their molecular profile. This was done to reveal potential signatures for response or resistance of the PDAC PDX models to the drug treatments. In conclusion, this published study strongly supports the importance and value of PDX models for improvement of therapies of PC and offers new options for pre-clinical testing of more effective therapies to treat PC. (Weblink)